Biofabricated soft network composites for cartilage tissue engineering

Biofabricated soft network composites for cartilage tissue engineering.

Articular cartilage from a material science point of view is a soft network composite that plays a critical role in load-bearing joints during dynamic loading. Its composite structure, consisting of a collagen fiber network and a hydrated proteoglycan matrix, gives rise to the complex mechanical properties of the tissue including viscoelasticity and stress relaxation. Melt electrospinning writi...

Nanomaterials for Cartilage Tissue Engineering

Importance of Floating Chondrons in Cartilage Tissue Engineering

BACKGROUND Dedifferentiation of chondrocytes remains a major problem for cartilage tissue engineering. Chondrocytes loss differentiated phenotype in in vitro culture that is undesired for repair strategies. The chondrocyte is surrounded by a pericellular matrix (PCM), together forming the chondron. PCM has a positive effect on the maintenance of chondrocyte phenotype during culture in compar...

Engineering cartilage tissue.

Cartilage tissue engineering is emerging as a technique for the regeneration of cartilage tissue damaged due to disease or trauma. Since cartilage lacks regenerative capabilities, it is essential to develop approaches that deliver the appropriate cells, biomaterials, and signaling factors to the defect site. The objective of this review is to discuss the approaches that have been taken in this ...

Tissue engineering of cartilage

The main goal of tissue engineering is to create artificial constructs that could repair or simply replace lost or damaged tissue. Common tissue engineering strategies involve the extraction of cells from a small biopsy of tissue for in vitro expansion. This culture can be carried out in a three dimensional (3D) scaffold that allows and induces the formation of new tissue after implantation. Fu...